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Welcome to the Tang Lab！

Our lab is committed to sharing our research and findings with the scientific community. Visit our publications page to view our latest research papers and scientific publications.

Cover Gallaries

The work of Dr. Zhongmin Tang and his collaborators has been featured on the front covers of numerous prestigious journals, highlighting their contributions to nanomaterials, biomedicine, and cutting-edge technologies. Notable publications include studies on mRNA delivery strategies, Fenton chemistry in cancer therapy, biodegradable nanoprodrugs, and innovative approaches in chemodynamic therapy. These cover articles, appearing in journals like Nature Reviews Materials, Chemical Reviews, PNAS, and Advanced Materials, emphasize the significant impact of their research in advancing medical science and nanotechnology.

Tongji University (From 2023.04)

  1. Tang Z, You X, Xiao Y, Chen W, Li Y, Huang X, Liu H, Xiao F, Liu C, Koo S, Kong N, Tao W*. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. Proceedings of the National Academy of Sciences USA 2023,120(44): e2304966120.

  2. Zixuan Lin,  Zhixin Chen,  Yiwei Chen,  Nan Yang,  Jianlin Shi,  Zhongmin Tang,  Changqing Zhang*,  Han Lin*,  Junhui Yin*. (2023, August). Hydrogenated silicene nanosheet functionalized scaffold enables immuno‐bone remodeling. Exploration. 2023, 3(4): 20220149.

  3. Zulmari Silva Pedraza, Yizhan Wang, Corey Carlos, Zhongmin Tang, Jun Li, Weibo Cai, Xudong Wang* (2023). Development of Ferroelectric P (VDF-TrFE) Microparticles for Ultrasound-Driven Cancer Cell Killing. ACS Applied Materials & Interfaces, 15(47), 54304-54311.

  4. Jiayang Yan, Zhongmin Tang, Yanan Li, Han Wang, Jessica C. Hsu, Mengmeng Shi, Zi Fu, Xiuru Ji, Weibo Cai*, Dalong Ni*, and Jieming Qu* (2023). Molybdenum Nanodots for Acute Lung Injury Therapy. ACS nano, 17(23), 23872-23888.

  5. Z. Tang*, F. Yu, J. C. Hsu, J. Shi, W. Cai*.Soybean Oil‐Derived Lipids for Efficient mRNA Delivery. Advanced Materials, 2024, 36(13): 2302901.

  6. Malih S, Lin W, Tang Z, DeLuca MC, Engle JW, Alirezapour B, Cai W, Rasaee MJ. Noninvasive PET imaging of tumor PD-L1 expression with 64Cu-labeled Durvalumab. American Journal of Nuclear Medicine and Molecular Imaging, 2024, 14(1): 31.

  7. Wu S, Xu T, Gao J, Zhang Q, Huang Y, Liu Z, Hao X, Yao Z, Hao X, Wu PY, Wu Y*, Yin B*, Tang Z*. (2024). Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles. European Journal of Nuclear Medicine and Molecular Imaging, 1-14.​

Before 04/2023

  1. Z. Tang, H Zhang, Y Liu, D Ni, H Zhang, J Zhang, Z Yao, M He, J Shi, W Bu*. (2017) Antiferromagnetic pyrite as the tumor microenvironment‐mediated nanoplatform for self‐enhanced tumor imaging and therapy. Advanced Materials 29 (47), 1701683. (High cited paper)

  2. Z. Tang, P. Zhao, D. Ni, Y. Liu, M. Zhang, H. Wang, H. Zhang, H. Gao, Z. Yao, W. Bu*. (2018) Pyroelectric nanoplatform for NIR-II-triggered photothermal therapy with simultaneous pyroelectric dynamic therapy. Materials Horizons 5 (5), 946-952.

  3. Z Tang, Y Liu, M He, W Bu*. (2019) Chemodynamic therapy: tumour microenvironment-mediated Fenton and Fenton‐like reactions. Angewandte Chemie International Edition 58 (4), 946-956. (High cited paper)

  4. Z Tang, Y Liu, D Ni, J Zhou, M Zhang, P Zhao, B Lv, H Wang, D Jin, W Bu*. (2020) Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy. Advanced Materials 32 (4), 1904011.

  5. Z. Tang, N. Kong, J. Ouyang, C. Feng, N. Y. Kim, X. Ji, C. Wang, O. C. Farokhzad, H. Zhang, W. Tao*. (2020) Phosphorus science-oriented design and synthesis of multifunctional nanomaterials for biomedical applications. Matter 2 (2), 297-322. (High cited paper)

  6. Z. Tang, N. Kong, X. Zhang, Y. Liu, P. Hu, S. Mou, P. Liljeström, J. Shi, W. Tan, J. S. Kim, Y. Cao, R. Langer, K. W. Leong, O. C. Farokhzad*, W. Tao*. (2020) A materials-science perspective on tackling COVID-19. Nature Reviews Materials 5 (11), 847-860. (Front Cover)

  7. Y. Xiao, Z. Tang (Co-first), J. Wang, C. Liu, N. Kong, O. C. Farokhzad*, W. Tao*. (2020) Oral insulin delivery platforms: Strategies to address the biological barriers. Angewandte Chemie International Edition 59 (45), 19787-19795.

  8. Z Tang, X Zhang, Y Shu, M Guo, H Zhang, W Tao*. (2021) Insights from nanotechnology in COVID-19 treatment. Nano Today 36, 101019. (High cited paper)

  9. Z Tang, P Zhao, H Wang, Y Liu*, W Bu*. (2021) Biomedicine meets Fenton chemistry. Chemical Reviews. 121, 4, 1981–2019. (High cited paper) (Front Cover)

  10. P. Zhao, Y. Jiang, Z. Tang*, Y. Li, B. Sun, Y. Wu, J. Wu, Y. Liu*, W. Bu*. (2021) Constructing Electron lever in Perovskite Nanocrystal to Regulate Local Electron Density for Intensive Chemodynamic Therapy. Angewandte Chemie 133(16), 8987-8994.

  11. Y. Xiao, Z. Tang (Co-first), X. Huang, J. Joseph, W. Chen, J. Zhou, N. Kong, N. Joshi, J. Du, W. Tao* (2021) Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes. Matter 4(10). 3269-3285.

  12. Z. Tang, Y. Xiao, N. Kong, C. Liu, W. Chen, X. Huang, D. Xu, J. Ouyang, C. Feng, C. Wang, J. Wang, H. Zhang, W. Tao* (2021) Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy. Acta Pharmaceutica Sinica B 11(11), 3447-3464.

  13. Y. You, Z. Tang*, H. Lin*, J. Shi. (2021) Emerging two-dimensional material nanozymes for theranostic nanomedicine. Biophysics Reports, 7. 159-172.

  14. M. Younis, Z. Tang*, W. Cai* (2022) Multimodality imaging of nanoparticle-based vaccines: Shedding light on immunology. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, e1807.

  15. Y. Xiao, Z. Tang (Co-first), X. Huang, W. Chen, J. Zhou, H. Liu, C. Liu, N. Kong*, W. Tao* (2022) Emerging mRNA technologies: delivery strategies and biomedical applications. Chemical Society Review, 51, 3828-3845. (Front Cover)

  16. Z. Tang, S. Wu, P. Zhao, H. Wang, D. Ni, H. Li, X. Jiang, Y. Wu, Y. Meng, Z. Yao*, W. Cai, W. Bu* (2022) Chemical Factory‐Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer. Advanced Science, 9, 2201232.

  17. X. Ji*, Z. Tang (Co-first), H. Liu, Y. Kang, L. Chen, J. Dong, W. Chen, N. Kong, W. Tao*, T. Xie* Thermoelectric effect mediated cancer Thermoelectric therapy and surgical adjuvant treatment (2022) Advanced Materials, 2207391.

  18. H. Wang, H. Gao, X. Jiang, P. Zhao, D. Ni, Z. Tang, Y. Liu*, X. Zheng*, W. Bu*. Regulating water states by vacancies for cancer therapy. Nano Today 37 (2021): 101099.

  19. D. Ni, J. Zhang, J. Wang, P. Hu, Y. Jin, Z. Tang, Z. Yao, W. Bu*, J. Shi*. Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent. ACS Nano 11 (4), 4256-4264.

  20. H. Zhang, Y. Wu, J. Wang, Z. Tang, Y. Ren, D. Ni, H. Gao, R. Song, T. Jin, Q. Li, W. Bu*, Z. Yao*. In Vivo MR Imaging of Glioma Recruitment of Adoptive T-Cells Labeled with NaGdF4-TAT Nanoprobes. Small 14 (3), 1702951.

  21. Y Liu, X Meng, H Wang, Z Tang, C Zuo, M He, W Bu*. Photoelectron Transfer at ZnTPyP Self-Assembly/TiO2 Interfaces for Enhanced Two-Photon Photodynamic Therapy. ACS applied materials & interfaces 10 (2), 1492-1498.

  22. M. Zhang, Z. Cui, R. Song, B. Lv, Z. Tang, X. Meng, X. Chen, X. Zheng, J. Zhang, Z. Yao, W. Bu*. SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy. Biomaterials 155, 135-144.

  23. H. Wang, B. Lv, Z. Tang, M. Zhang, W. Ge, Y. Liu, X. He, K. Zhao, X. Zheng, M. He, W. Bu*. Scintillator-based nanohybrids with sacrificial electron prodrug for enhanced x-ray-induced photodynamic therapy. Nano letters 18 (9), 5768-5774.

  24. R. Song, M. Zhang, Y. Liu, Z. Cui, H. Zhang, Z. Tang, X. Chen, H. Wu, Z. Yao, M. He, W. Bu*. A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor. Biomaterials 175, 123-133.

  25. Y. Liu, Y. Jiang, M. Zhang, Z. Tang, M. He, W. Bu*. Modulating hypoxia via nanomaterials chemistry for efficient treatment of solid tumors. Accounts of Chemical Research 51 (10), 2502-2511.

  26. A. Shen, X. Meng, X. Gao, X. Xu, C. Shao, Z. Tang, Y. Liu, W. Bu*, P. Wang*. An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field. Advanced Functional Materials 29 (2), 1803832.

  27. P. Zhao, Z. Tang, X. Chen, Z. He, X. He, M. Zhang, Y. Liu, D. Ren, K. Zhao, W. Bu*. Ferrous-cysteine–phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy. Materials Horizons 6 (2), 369-374.

  28. M. Zhang, R. Song, Y. Liu, Z. Yi, X. Meng, J. Zhang, Z. Tang, Z. Yao, Y. Liu, X. Liu*, W. Bu*. Calcium-overload-mediated tumor therapy by calcium peroxide nanoparticles. Chem 5 (8), 2171-2182.

  29. X. Sui, T. Jin, T. Liu, S. Wu, Y. Wu, Z. Tang, Y. Ren, D. Ni, Z. Yao, H. Zhang. Tumor Immune Microenvironments (TIMEs): Responsive Nanoplatforms for Antitumor Immunotherapy. Front Chem. 2020; 8: 804.

  30. C. Wang, P. Zhao, D. Jiang, G. Yang, Y. Xue, Z. Tang, M. Zhang, H. Wang, X. Jiang, Y. Wu, Y. Liu, W. Zhang, W. Bu*. In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor. ACS Applied Materials & Interfaces 12 (5), 5624-5632.

  31. Y. Liu, S. Wu, Y. Liu, H. Zhang, M. Zhang, Z. Tang, Y. Wang, T. Gong, Z. Yao, X. Fang, W. Bu*. Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy. Biomaterials 234, 119762.

  32. W. Su, H. Wang, T. Wang, X. Li, Z. Tang, S. Zhao, M. Zhang, D. Li, X. Jiang, T. Gong, W. Yang, C. Zuo*, Y. Wu, W. Bu*. Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy. Advanced Science 7 (10), 1903585.

  33. C. Feng, J. Ouyang, Z. Tang, N. Kong, Y. Liu, L. Fu, X. Ji, T. Xie, O. C. Farokhzad, W. Tao*. Germanene-Based Theranostic Materials for Surgical Adjuvant Treatment: Inhibiting Tumor Recurrence and Wound Infection. Matter 3, 127–144.

  34. A. Xie, S. Hanif, J. Ouyang, Z. Tang, N. Kong, N. Y. Kim, B. Qi, D. Patel, B. Shi, W. Tao*. Stimuli-responsive prodrug-based cancer nanomedicine. EBioMedicine 56 (2020) 102821.

  35. J. Ouyang, X. Ji, X. Zhang, C. Feng, Z. Tang, N. Kong, A. Xie, J. Wang, X. Sui, L. Deng, Y. Liu, J. S. Kim, Y. Cao, W. Tao*. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment. Proceedings of the National Academy of Sciences 117 (46), 28667-28677.

  36. J. Ouyang, Z. Tang, N. Farokhzad, N. Kong, N. Y. Kim, C. Feng, S. Blake, Y. Xiao, C. Liu, T. Xie, W. Tao*. Ultrasound mediated therapy: Recent progress and challenges in nanoscience. Nano Today 35, 100949.

  37. B. Lv, H. Zhang, X. Zheng, H. Wang, W. Ge, Y. Ren, Z. Tan, M. Zhang, Z. Tang, Y. Liu, L. Zhang, Y. Wu, X. Jiang, W. Bu*. Structure-oriented catalytic radiosensitization for cancer radiotherapy. Nano Today 35, 100988.

  38. Z. Zhang, Z. Tang, N. Farokhzad, T. Chen, W. Tao*. Sensitive, Rapid, Low-Cost, and Multiplexed COVID-19 Monitoring by the Wireless Telemedicine Platform. Matter 3 (6), 1818-1820.

  39. C. Liu, J. Shin, S. Son, Y. Choe, N. Farokhzad, Z. Tang, Y. Xiao, N. Kong, T. Xie, J. S. Kim, W. Tao*. (2021). Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine. Chemical Society Reviews. 50(4), 2260-2279.

  40. W. Chen, C. Liu, X. Ji, J. Joseph, Z. Tang, J. Ouyang, Y. Xiao, N. Kong, N. Joshi, O. C. Farokhzad, W. Tao*, T. Xie*. Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy. Angewandte Chemie. 133(13), 7231-7240.

  41. H. Wang, H. Gao, X. Jiang, P. Zhao, D. Ni, Z. Tang, Y. Liu, X. Zheng, W. Bu*. (2021) Regulating water states by vacancies for cancer therapy. Nano Today, 37, 101099.

  42. X. Ji, L. Ge, C. Liu, Z. Tang, Y. Xiao, W. Chen, Z. Lei, W. Gao, S. Blake, D. De, B. Shi, X. Zheng, N. Kong, X. Zhang, W. Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics. Nature Communications 12.1 (2021): 1-17.

  43. X. Zhu, X. Duan, Y. Hu, Z. Tang, C. Miao, W. Tao*, J. Wu. One-step and facile synthesis of peptide-like poly(melphalan) nanodrug for cancer therapy. Nano Today 37 (2021): 101098.

  44. J. Ouyang, L. Zhang, L. Li, W. Chen, Z. Tang, X. Ji, C. Feng, N. Tao, T. Chen*, Y. Liu*, W. Tao* Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics. Nano-Micro Letters, 13(1), 1-18.

  45. C. Liu, S. Sun, Q. Feng, G. Wu, Y. Wu, N. Kong, Z. Yu, J. Yao, X. Zhang, W. Chen, Z. Tang, Y. Xiao, X. Huang, A. Lv, C. Yao, H. Cheng, A. Wu*, T. Xie*, W. Tao*. Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therap. Advanced Materials, 33(37), 2102054.

  46. X. Huang, G. Wu, C. Liu, X. Hua, Z. Tang, Y. Xiao, W. Chen, J. Zhou, N. Kong, P. Huang, J. Shi, W. Tao* (2021) Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy. Nano Letters, https://doi.org/10.1021/acs.nanolett.1c03539.

  47. Guo, J., Zhao, Z., Shang, Z. F., Tang, Z., Zhu, H., & Zhang, K*. Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife.Exploration. 2023, 3(2): 20220119.

  48. Hsu JC, Tang Z, Eremina OE, Sofias AM, Lammers T, Lovell JF, Zavaleta C, Cai W, Cormode DP*. Eremina O E, et al. Nanomaterial-based contrast agents. Nature Reviews Methods Primers, 2023, 3(1): 30.

  49. H.-J. Liu, W. Chen, G. Wu, J. Zhou, C. Liu, Z. Tang, X. Huang, J. Gao, Y. Xiao, N. Kong, N. Joshi, Y. Cao, R. Abdi, W. Tao*. (2023). Glutathione‐scavenging nanoparticle‐mediated PROTACs delivery for targeted protein degradation and amplified antitumor effects. Advanced Science, 10(16), 2207439.

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